{"id":7262,"date":"2023-03-14T18:24:40","date_gmt":"2023-03-15T01:24:40","guid":{"rendered":"https:\/\/www.bluerocktx.com\/?p=7262"},"modified":"2023-06-26T14:30:24","modified_gmt":"2023-06-26T18:30:24","slug":"bluerock-therapeutics-to-incorporate-wearable-and-invisible-contactless-digital-health-technologies-from-rune-labs-and-emerald-innovations-in-parkinsons-disease-clinical-trial","status":"publish","type":"post","link":"https:\/\/www.bluerocktx.com\/bluerock-therapeutics-to-incorporate-wearable-and-invisible-contactless-digital-health-technologies-from-rune-labs-and-emerald-innovations-in-parkinsons-disease-clinical-trial\/","title":{"rendered":"BlueRock Therapeutics to incorporate wearable and invisible contactless digital health technologies from Rune Labs and Emerald Innovations in Parkinson\u2019s disease clinical trial"},"content":{"rendered":"<ul>\n<li><strong>Rune Labs\u2019\u00a0StriveStudy\u00a0platform and Emerald Innovations\u2019 Emerald wireless monitoring sensor will passively capture data on Parkinson\u2019s disease impact on function of fifty study participants in BlueRock\u2019s global non-interventional clinical study.<\/strong><\/li>\n<li><strong>Collaboration is part of BlueRock\u2019s commitment to change the standard of care for treating Parkinson\u2019s disease which includes a first-in-class stem cell-based therapy bemdaneprocel (BRT-DA01), currently in a phase 1 clinical study.<\/strong><\/li>\n<li><strong>Results from the Phase 1 study are expected to be announced in the second half of 2023.<\/strong><\/li>\n<\/ul>\n<p><strong>CAMBRIDGE Mass., March 14, 2023<\/strong>\u00a0\u2013 BlueRock Therapeutics LP, a clinical stage biopharmaceutical company and wholly-owned, independently operated subsidiary of Bayer AG, today announced a collaboration with Rune Labs and Emerald Innovations focused on using wearable and invisible contactless digital health technology to improve monitoring and data collection for Parkinson\u2019s disease clinical trials.<\/p>\n<p>Currently, monitoring and data collection in Parkinson\u2019s disease clinical trials combine subjective patient-reporting tools such as diaries and questionnaires with periodic neurological and mobility assessments in a clinical setting that only capture a specific moment in time. Unfortunately, this approach fails to give a full, real-time picture of disease progression and the impact of a patient\u2019s daily experience with Parkinson\u2019s symptoms such as uncontrolled tremors and muscle movement, rigidity, restless sleep and loss of balance.<\/p>\n<p>\u201cParkinson\u2019s disease is incredibly complex, with symptoms often varying hour to hour through the course of the day,\u201d said Seth Ettenberg, President and CEO of BlueRock Therapeutics. \u201cNew tools and approaches are needed to ease the reporting burden on patients in trials and to measure and assess disease progression more effectively. We are excited to be working with the pioneering teams at Rune Labs and Emerald Innovations to harness the power of their digital health technologies to collect an unbiased, objective, and continuous measure of disease impact on function that will help us develop more effective therapies.\u201d<\/p>\n<p>BlueRock is working to change the standard of care for treating Parkinson\u2019s disease and is currently testing a first-in-class stem cell-based therapy, bemdaneprocel (BRT-DA01), in a Phase 1 clinical study. Results from the Phase 1 study are expected to be announced in the second half of 2023. The company is also enrolling patients in a two-year global non-interventional study focused on gaining a better understanding of patients\u2019 day to day experience with Parkinson\u2019s disease.<\/p>\n<p>In the non-interventional study, the Rune Labs and Emerald technologies will be used to monitor the daily activities and measure key markers of disease progression in 50 patients and monitor their daily activities.<\/p>\n<p>Rune Labs\u2019 StriveStudy platform works directly with the wearable Apple Watch and Apple\u2019s Movement Disorder API and will be used to record real-time measurement of general mobility, tremor intensity, dyskinesia, and involuntary muscle movements of patients in the non-interventional study. BlueRock can leverage StriveStudy to monitor patient compliance by tracking how often they wear the Apple Watch in the study, as well as to improve the study experience for patients by streamlining data collection<\/p>\n<p>\u201cThis collaboration is shifting the paradigm for Parkinson\u2019s disease drug development,\u201d said Brian Pepin, CEO of Rune Labs. \u201cTo give hope to Parkinson\u2019s patients, we need to push neurology drug development into the future, and we believe that Rune Labs\u2019 precision neurology platform can support this goal, much as precision medicine pioneers drove the oncology field forward.\u201d<\/p>\n<p>Emerald Innovations\u2019 Emerald monitoring biosensor belongs to a new class of sensors called \u201cinvisibles\u201d that extract health metrics from radio signals, without wearable devices. Placed in the homes of study participants, the Emerald sensor continuously analyses the surrounding radio signals using artificial intelligence. In this study it will collect data on patients\u2019 gait speed, mobility, and sleep quality.<\/p>\n<p>\u201cEmerald is built on a decade of research and has demonstrated strong correlation with the gold standards in Parkinson\u2019s, while allowing clinical trials to reach robust evidence faster and with a smaller number of patients. Our collaboration with BlueRock enables a data-driven clinical trial in Parkinson\u2019s while patients go about their normal lives,\u201d said Dr. Dina Katabi, Co-Founder of Emerald Innovations.<\/p>\n<p>BlueRock will compare data from the use of both technologies to standard measurement and feasibility tools to gauge the feasibility of their use for future clinical studies for bemdaneprocel (BRT-DA01).<\/p>\n<p><strong>About the bemdaneprocel (BRT-DA01) Phase 1 Trial<\/strong><\/p>\n<p>The primary objective of the\u00a0Ph1\u00a0trial is to assess the safety and tolerability of bemdaneprocel (BRT-DA01) transplantation at one-year post-transplant. The secondary objectives of the trial are to assess the evidence of transplanted cell survival and motor effects at one- and two-years post-transplant, to evaluate continued safety and tolerability at two years, and to assess feasibility of transplantation.<\/p>\n<p>In the United States, the trial was initiated at Weill Cornell Medicine with Dr. Harini Sarva, M.D. as the Principal Investigator (PI) and first surgeries being performed by Dr. Viviane Tabar, Chair of the Department of Neurosurgery at Memorial Sloan Kettering Cancer Center. Dr. Tabar has financial interests related to BlueRock. Memorial Sloan Kettering (MSK) has institutional financial interests related to BlueRock. Additional Neurology sites were added at the University of California, Irvine, under the guidance of Dr. Claire Henchcliffe, M.D., D.Phil., F.A.A.N., F.A.N.A. (PI), and at the University Health Network (UHN), under the guidance of Dr. Lozano, O.C., M.D., Ph.D., F.R.C.S.C., F.R.S.C., F.C.A.H.S. (PI) and Dr. Alfonso Fasano, M.D., PhD., Chair in Neuromodulation and Multi-Disciplinary Care, UHN and UoT.<\/p>\n<p>More information about the Phase 1 trial is available at\u00a0<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04802733?term=04802733&amp;draw=2&amp;rank=1\" target=\"_blank\" rel=\"noopener\">clinicaltrials.gov<\/a>\u00a0(NCT#04802733)<\/p>\n<p>More information about the non-interventional study is available at\u00a0<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05363046?term=BlueRock+Therapeutics&amp;cond=Parkinson+Disease&amp;draw=2&amp;rank=1\" target=\"_blank\" rel=\"noopener\">clinicaltrials.gov<\/a>\u00a0(NCT#05363046)<\/p>\n<p><strong>About Parkinson\u2019s Disease<\/strong><\/p>\n<p>Parkinson\u2019s disease is a progressive neurodegenerative disorder caused by nerve cell damage in the brain, leading to decreased dopamine levels. The worsening of motor and non-motor symptoms is caused by the loss of dopamine-producing neurons. At diagnosis, it is estimated that patients have already lost 60-80% of their dopaminergic neurons. Parkinson\u2019s disease often starts with a tremor in one hand. Other symptoms are rigidity, cramping and slowness of movement (bradykinesia). According to the Parkinson\u2019s Foundation, more than 10 million people worldwide suffer from Parkinson\u2019s disease, with one million living in the United States. DA01 is being clinically evaluated in a subset of patients with Parkinson\u2019s disease, where regular medications are no longer fully effective.<\/p>\n<p><strong>About BlueRock Therapeutics\u00a0LP<\/strong><\/p>\n<p>BlueRock Therapeutics LP is a clinical stage cell therapy company focused on creating cellular medicines to reverse devastating diseases. Our\u00a0cell+gene\u00a0platform is harnessing the power of cells to create a pipeline of new medicines for patients suffering from neurological, cardiovascular, immunological, and ophthalmic diseases. Our lead clinical program, bemdaneprocel, (BRT-DA01) is in Phase 1 clinical trials for Parkinson\u2019s disease. We were founded in 2016 by Versant Ventures and Bayer AG and became a wholly owned, independently operated subsidiary of Bayer AG in late 2019 as a cornerstone of its newly formed Cell &amp; Gene Therapy Platform. Our culture is defined by the courage to persist regardless of the challenge, the urgency to transform medicine and deliver hope, integrity guided by mission, and community-mindedness with the understanding that we are all part of something bigger than ourselves. For more information, visit\u00a0www.bluerocktx.com<\/p>\n<p><strong>About Bayer<\/strong><\/p>\n<p>Bayer is a global enterprise with core competencies in the life science fields of health care and nutrition. Its products and services are designed to help people and the planet thrive by supporting efforts to master the major challenges presented by a growing and aging global population. Bayer is committed to driving sustainable development and generating a positive impact with its businesses. At the same time, the Group aims to increase its earning power and create value through innovation and growth. The Bayer brand stands for trust, reliability and quality throughout the world. In fiscal 2022, the Group employed around 101,000\u00a0people and had sales of 50.7\u00a0billion euros. R&amp;D expenses before special items amounted to 6.2\u00a0billion euros. For more information, go to www.bayer.com.<\/p>\n<p><strong>Forward Looking Statements<\/strong><\/p>\n<p>Certain statements in this press release are forward-looking within the meaning of the Private Securities Litigation Reform Act of 1995. These statements may be identified by the use of forward-looking words such as \u201canticipate,\u201d \u201cbelieve,\u201d \u201cforecast,\u201d \u201cestimate\u201d and \u201cintend,\u201d among others. These forward-looking statements are based on the Company\u2019s current expectations of BlueRock and actual results could differ materially. There are a number of factors that could cause actual events to differ materially from those indicated by such forward-looking statements. These factors include, but are not limited to, the timing of our clinical trial for bemdaneprocel (BRT-DA01); our results regarding the safety, tolerance and efficacy of DA01 cell transplantation for patients with Parkinson\u2019s disease; and ongoing FDA and other regulatory requirements regarding the development of bemdaneprocel (BRT-DA01). As with any pharmaceutical under development, there are significant risks in the development, regulatory approval and commercialization of new products. Except as expressly required by law, BlueRock does not undertake an obligation to update or revise any forward-looking statement. All of the Company\u2019s forward-looking statements are expressly qualified by all such risk factors and other cautionary statements. The information set forth herein speaks only as of the date hereof.<\/p>\n<p>This release may contain forward-looking statements based on current assumptions and forecasts made by Bayer management. Various known and unknown risks, uncertainties and other factors could lead to material differences between the actual future results, financial situation, development or performance of the company and the estimates given here. These factors include those discussed in Bayer\u2019s public reports which are available on the Bayer website at\u00a0www.bayer.com. The company assumes no liability whatsoever to update these forward-looking statements or to conform them to future events or developments.<\/p>\n<p><strong>Media Contact<\/strong><\/p>\n<p>Jeff Lockwood<br \/>\nVice President, Corporate Communications<br \/>\np. +1 617.510.6997<br \/>\ne. <a href=\"mailto:jlockwood@bluerock.com\">jlockwood@bluerock.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Rune Labs\u2019\u00a0StriveStudy\u00a0platform and Emerald Innovations\u2019 Emerald wireless monitoring sensor will passively capture data on Parkinson\u2019s disease impact on function of fifty study participants in BlueRock\u2019s global non-interventional clinical study. Collaboration is part of BlueRock\u2019s commitment to change the standard of care for treating Parkinson\u2019s [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":7708,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[45],"tags":[56,57],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>BlueRock Therapeutics to incorporate wearable and invisible contactless digital health technologies from Rune Labs and Emerald Innovations in Parkinson\u2019s disease clinical trial - BlueRock Therapeutics LP<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.bluerocktx.com\/bluerock-therapeutics-to-incorporate-wearable-and-invisible-contactless-digital-health-technologies-from-rune-labs-and-emerald-innovations-in-parkinsons-disease-clinical-trial\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"BlueRock Therapeutics to incorporate wearable and invisible contactless digital health technologies from Rune Labs and Emerald Innovations in Parkinson\u2019s disease clinical trial - BlueRock Therapeutics LP\" \/>\n<meta property=\"og:description\" content=\"Rune Labs\u2019\u00a0StriveStudy\u00a0platform and Emerald Innovations\u2019 Emerald wireless monitoring sensor will passively capture data on Parkinson\u2019s disease impact on function of fifty study participants in BlueRock\u2019s global non-interventional clinical study. 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