{"id":7218,"date":"2019-06-27T17:46:01","date_gmt":"2019-06-28T00:46:01","guid":{"rendered":"https:\/\/www.bluerocktx.com\/?p=7218"},"modified":"2023-06-26T14:12:07","modified_gmt":"2023-06-26T18:12:07","slug":"hla-e-expressing-pluripotent-stem-cells-escape-allogeneic-responses-and-lysis-by-nk-cells","status":"publish","type":"post","link":"https:\/\/www.bluerocktx.com\/hla-e-expressing-pluripotent-stem-cells-escape-allogeneic-responses-and-lysis-by-nk-cells\/","title":{"rendered":"HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells"},"content":{"rendered":"<p>Gornalusse et al demonstrate that master cell banks of pluripotent stem cells can be gene edited to ablate HLA receptors and avoid T cell recognition. In addition, these banks are engineered to express a recombinant receptor to prevent innate cell clearance. This escape from immune surveillance is demonstrated using in vitro assays and validated in pre-clinical models. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5548598\/\" target=\"_blank\" rel=\"noopener\">Read more<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Gornalusse et al demonstrate that master cell banks of pluripotent stem cells can be gene edited to ablate HLA receptors and avoid T cell recognition. In addition, these banks are engineered to express a recombinant receptor to prevent innate cell clearance. This escape from [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":7700,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[50],"tags":[43],"class_list":["post-7218","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-insights","tag-immunology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells - BlueRock Therapeutics LP<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.bluerocktx.com\/hla-e-expressing-pluripotent-stem-cells-escape-allogeneic-responses-and-lysis-by-nk-cells\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells - BlueRock Therapeutics LP\" \/>\n<meta property=\"og:description\" content=\"Gornalusse et al demonstrate that master cell banks of pluripotent stem cells can be gene edited to ablate HLA receptors and avoid T cell recognition. 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