HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells

Gornalusse et al demonstrate that master cell banks of pluripotent stem cells can be gene edited to ablate HLA receptors and avoid T cell recognition. In addition, these banks are engineered to express a recombinant receptor to prevent innate cell clearance. This escape from immune surveillance is demonstrated using in vitro assays and validated in pre-clinical models. Read more.